Black Diamond Therapeutics Inc

DMPK Scientist / DMPK Senior Scientist / DMPK Principal Scientist,

Job Locations US-MA-Cambridge
Research - Chemistry
Regular Full-Time



Black Diamond Therapeutics is a precision oncology medicine company pioneering the discovery and development of small molecule, tumor-agnostic therapies. Black Diamond targets undrugged mutations in patients with genetically defined cancers for whom limited treatment options currently exist. Black Diamond is built upon a deep understanding of cancer genetics, protein structure and function, and medicinal chemistry. The Company’s proprietary technology platform, Mutation-Allostery-Pharmacology, or MAP, platform, is designed to allow Black Diamond to analyze population-level genetic sequencing data to identify oncogenic mutations that promote cancer across tumor types, group these mutations into families and develop a single small molecule therapy in a tumor-agnostic manner that targets a specific family of mutations.


Black Diamond is currently seeking a DMPK project representative. Reporting to the Director, DMPK, the incumbent will be the drug metabolism and pharmacokinetics (DMPK) lead on project teams developing small molecule modulators as precision cancer medicines. We are looking for a consummate team player seeking a collaborative environment in which to grow their career in drug discovery and development.  


  • Oversight of activities at CROs, including in vitro ADME, PK, bioanalysis and PK/PD modeling
  • Be the functional area representative for DMPK on project teams
  • Design, analyze and interpret preclinical DMPK studies in support of program goals
  • Use a broad array of DMPK data to enable integrated analyses of biopharmaceutics, drug metabolism, PK/PD, human PK/dose projections and DDI risk
  • Contribute to study reports and relevant sections of regulatory documents


  • BS, MS or Ph.D. with 8, 6, or 3+ years of experience, respectively, with a focus in pharmacokinetics, pharmacology or related discipline
  • Technical depth and a broad understanding of small molecule bioanalysis (LC-MS/MS), drug metabolism  in vitro assays including metabolic stability, enzyme inhibition/induction/phenotyping, protein binding, and pharmacokinetics with proficiency in Phoenix WinNonlin or similar
  • Experience optimizing and characterizing the ADME properties of small molecule drug candidates with expertise in the interplay between DMPK parameters, physicochemical and molecular properties
  • Experience leading DMPK on projects particularly in discovery and early development
  • Proficient in the management of activities at contract research organizations and comfortable working in virtual outsourced model
  • Excellent communication and organizational skills; comfortable navigating complexity and ambiguity in a fast-paced environment interacting with consultants, external vendors and internal cross-functional, global project teams.
  • One or more of the following areas of expertise would be considered a plus: PK modeling, PK/PD modeling, GLP bioanalysis.
  • Familiarity with external regulatory requirements, and experience authoring and reviewing PK sections of regulatory dossiers
  • To Apply:
  • Please forward applications via email only to including a cover letter and resume. In the e-mail subject line, please indicate the position title Scientist/Senior/Principal Scientist, DMPK.


The physical demands described here are representative of those that must be met by an employee to successfully perform he essential functions of this job.


While performing the duties of this job, the employee is occasionally required to stand; walk; sit; used hands to fingers, handle, or feel objects, tools, or controls; reach with hands and arms; climb be stairs; talk or hear. The employee must occasionally lift or move office products and supplies, up to 20 lbs.


Black Diamond Therapeutics is an equal opportunity employer and welcomes and encourages all applications.  Diversity and inclusion are important core values and will encourage our creativity and growth as a company.  Accommodations are available on request for candidates taking part in all aspects of the selection process.  We thank all applicants for their interest, however, only those selected will be invited for an interview.


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